Join Us

 

Fulcrum Therapeutics is looking for exceptional individuals who share our passion to create new medicines to deliver a new future for patients and their families by unlocking gene regulation in disease.

Our culture celebrates innovation and excellence, and if you want to experience being part of a team committed to delivering revolutionary science that will ultimately make a difference in patients’ lives, we invite you to explore Fulcrum’s career opportunities.

We offer a stimulating environment, tremendous growth opportunities as well as a comprehensive compensation and benefits package.

To be considered for an opportunity at Fulcrum Therapeutics, please submit your CV with the title of the position in the subject line to careers@fulcrumtx.com.

  • Senior Scientist, Chemistry

    Description

    We are seeking a highly motivated individual to be responsible for the design, synthesis, purification and characterization of small-molecule drug candidates in target validation, hit-to-lead and lead optimization projects in collaboration with external CROs. The successful candidate must have a demonstrated ability to innovate across the full spectrum of medicinal chemistry projects. In addition, he/she will engage in synthetic and medicinal chemistry problem solving and work with team members across disciplines to analyze diverse data sets to build structure-activity relationships and drive programs. As a Senior Scientist, the candidate will have collaborative engagement with the external scientific community and make direct contributions to Fulcrum’s external reputation.

    Responsibilities

    • Lead the external execution of design, synthesis, purification and characterization of bioactive compounds
    • Facilitate the design of new bioactive compounds by interacting with other chemists and biologists to optimize DMPK, in vitro, and in vivo pharmacology properties.
    • Lead and oversee effective interactions with external CROs.
    • Monitor and evaluate tasks to meet project time frames.

    Qualifications

    • PhD in synthetic organic chemistry or equivalent.
    • Structure-based drug design experience preferred.
    • At least 3-10 years of industry experience strongly preferred.
    • High level of creativity and productivity with strong synthetic chemistry problem solving skills.
    • Demonstrated excellence in organic synthesis, conversant with the current literature.
    • Ability to champion chemistry efforts into new directions to achieve project milestones.
    • Strong evidence of conceptual thinking, active follow-through and vigorous scientific curiosity.
    • Proven ability to work well with others in a dynamic and highly collaborative environment.
    • Exceptional interpersonal, verbal and written communication skills.
  • Computational Biologist

    Description

    We are seeking a highly motivated Scientist or Sr. Scientist to join our efforts at Fulcrum. This individual will focus primarily on next generation sequencing data in conjunction with human or model organism phenotypic data as it relates to our therapeutic programs.

    Responsibilities

    • Analyze genome, epigenome, transcriptome, and proteomic datasets
    • Contribute to experimental study design
    • Involved with therapeutic target and biomarker identification
    • Adjusts to new data and changing project needs

    Requirements

    • An advanced degree or significant experience in computational biology, bioinformatics, molecular biology, computer science/engineering, statistics or related areas
    • Intermediate to advanced programming skills (i.e. Python, R)
    • Experience with high performance computing, preferably on the cloud (i.e. AWS)
    • Experience with open source NGS analysis software, analysis pipelines
    • Experience with Jupyter Notebooks, Github or related tools
    • Knowledge of publicly available databases (i.e. ENCODE, GEO)
    • Familiarity with pathway analysis
    • Good grasp of transcriptional and epigenetic biology; wet lab experience is a plus
    • Good grasp of transcriptional and epigenetic biology; wet lab experience is a plus
    • Evidence of maturity, resourcefulness, and leadership potential
    • Team oriented, highly collaborative
    • Excellent oral and written communication skills, fluency in English
  • Data Scientist – Machine Learning and Statistics

    Description

    We’re seeking a highly motivated individual at the Scientist or Sr. Scientist level to join our efforts at Fulcrum. This position will focus primarily on next generation sequencing data in conjunction with human or model organism phenotypic data as it relates to our therapeutic programs.

    Responsibilities

    • This position will focus on the development and application of statistical methods for the integrated analysis of large­scale bioinformatics datasets
    • Has experience with a wide array of machine learning algorithms and data mining methods (i.e. time series analysis, state space models, adaptive filtering, mixed effect models, hierarchical Bayes, Markov models, decision trees, boosting, random forests, support vector machines)
    • Perform exploratory data analysis of very large datasets from varying sources, draw inferences and insights to design or tune statistical models/learning algorithms for identifying genes predictive of phenotypes or clinical outcomes.
    • Evaluate fits, error metrics and model diagnostics to assess and improve model performance.
    • Curate large molecular and phenotypic datasets.
    • Interpret analysis to a broad array of wet lab scientists.

    Requirements

    • An advanced degree in a relevant technical field (i.e. Bioinformatics, Statistics, Computer Science, Engineering, Physics, Math, Finance)
    • Intermediate to advanced programming skills (i.e. Python, C++, Scala)
    • Expert knowledge of a statistical analysis package (i.e. R, Matlab, SAS)
    • Experience with high performance computing, preferably on the cloud (i.e. AWS)
    • Proficient with data visualization techniques
    • Experience with Hadoop/Map-Reduce/Spark and related tools
    • Good publication record
    • Evidence of maturity, resourcefulness, and leadership potential
    • Prefers team oriented, collaborative work environments
    • Excellent oral and written communication skills, fluency in English

Note to Recruitment Agencies: Please do not forward any agency resumes. Fulcrum Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Equal Opportunity Employer M/F/D/V