Join Us

 

Fulcrum Therapeutics is looking for exceptional individuals who share our passion to create new medicines to deliver a new future for patients and their families by unlocking gene regulation in disease.

Our culture celebrates innovation and excellence, and if you want to experience being part of a team committed to delivering revolutionary science that will ultimately make a difference in patients’ lives, we invite you to explore Fulcrum’s career opportunities.

We offer a stimulating environment, tremendous growth opportunities as well as a comprehensive compensation and benefits package.

To be considered for an opportunity at Fulcrum Therapeutics, please submit your CV with the title of the position in the subject line to careers@fulcrumtx.com.

  • Computational Biologist

    Description

    We are seeking a highly motivated Scientist or Sr. Scientist to join our efforts at Fulcrum. This individual will focus primarily on next generation sequencing data in conjunction with human or model organism phenotypic data as it relates to our therapeutic programs.

    Responsibilities

    • Analyze genome, epigenome, transcriptome, and proteomic datasets
    • Contribute to experimental study design
    • Involved with therapeutic target and biomarker identification
    • Adjusts to new data and changing project needs

    Requirements

    • An advanced degree or significant experience in computational biology, bioinformatics, molecular biology, computer science/engineering, statistics or related areas
    • Intermediate to advanced programming skills (i.e. Python, R)
    • Experience with high performance computing, preferably on the cloud (i.e. AWS)
    • Experience with open source NGS analysis software, analysis pipelines
    • Experience with Jupyter Notebooks, Github or related tools
    • Knowledge of publicly available databases (i.e. ENCODE, GEO)
    • Familiarity with pathway analysis
    • Good grasp of transcriptional and epigenetic biology; wet lab experience is a plus
    • Good grasp of transcriptional and epigenetic biology; wet lab experience is a plus
    • Evidence of maturity, resourcefulness, and leadership potential
    • Team oriented, highly collaborative
    • Excellent oral and written communication skills, fluency in English
  • Data Scientist – Machine Learning and Statistics

    Description

    We’re seeking a highly motivated individual at the Scientist or Sr. Scientist level to join our efforts at Fulcrum. This position will focus primarily on next generation sequencing data in conjunction with human or model organism phenotypic data as it relates to our therapeutic programs.

    Responsibilities

    • This position will focus on the development and application of statistical methods for the integrated analysis of large­scale bioinformatics datasets
    • Has experience with a wide array of machine learning algorithms and data mining methods (i.e. time series analysis, state space models, adaptive filtering, mixed effect models, hierarchical Bayes, Markov models, decision trees, boosting, random forests, support vector machines)
    • Perform exploratory data analysis of very large datasets from varying sources, draw inferences and insights to design or tune statistical models/learning algorithms for identifying genes predictive of phenotypes or clinical outcomes.
    • Evaluate fits, error metrics and model diagnostics to assess and improve model performance.
    • Curate large molecular and phenotypic datasets.
    • Interpret analysis to a broad array of wet lab scientists.

    Requirements

    • An advanced degree in a relevant technical field (i.e. Bioinformatics, Statistics, Computer Science, Engineering, Physics, Math, Finance)
    • Intermediate to advanced programming skills (i.e. Python, C++, Scala)
    • Expert knowledge of a statistical analysis package (i.e. R, Matlab, SAS)
    • Experience with high performance computing, preferably on the cloud (i.e. AWS)
    • Proficient with data visualization techniques
    • Experience with Hadoop/Map-Reduce/Spark and related tools
    • Good publication record
    • Evidence of maturity, resourcefulness, and leadership potential
    • Prefers team oriented, collaborative work environments
    • Excellent oral and written communication skills, fluency in English

Note to Recruitment Agencies: Please do not forward any agency resumes. Fulcrum Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Equal Opportunity Employer M/F/D/V