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Fulcrum Therapeutics is looking for exceptional individuals who share our passion to create new medicines to deliver a new future for patients and their families by unlocking gene regulation in disease.

Our culture celebrates innovation and excellence, and if you want to experience being part of a team committed to delivering revolutionary science that will ultimately make a difference in patients’ lives, we invite you to explore Fulcrum’s career opportunities.

We offer a stimulating environment, tremendous growth opportunities as well as a comprehensive compensation and benefits package.

To be considered for an opportunity at Fulcrum Therapeutics, please submit your CV with the title of the position in the subject line to careers@fulcrumtx.com.

  • Director of in vivo Pharmacology

    Description

    Fulcrum Therapeutics is pioneering small molecule therapeutic approaches to gene regulation in genetically defined diseases. The current opening offers the opportunity to lead in vivo pharmacology efforts and research programs in a fast-paced, innovative environment in the Biology Team. This role will include oversight of novel disease models whereby human neural precursor or myoblast disease and isogenic control cells are engrafted to build rodent models in support of our portfolio focused on monogenic neuromuscular disorders. The position will focus on design and execution of studies aimed at building pharmacologic relationships between drug exposure, target engagement, pharmacodynamic markers and disease gene expression in rodents and large animals together with external CROs. The candidate will also lead collaborations with our Scientific Founders, Advisory Board members, and key scientific leaders. This role will lead projects and be responsible for progressing therapeutic candidates from early discovery to IND-enabling studies. We are looking for excellent candidates to join our multidisciplinary team in an exciting and dynamic R&D environment.

    Responsibilities

    • Work with the team to prioritize therapeutic target and disease selection.
    • Lead therapeutic program efforts from target validation through to candidate selection, and collaborate with translation medicine colleagues to transition into Phase 1 clinical trials.
    • Build pharmacologic in vitro characterization and selection criteria to progress therapeutic candidates into in vivo studies.
    • Design and manage preclinical in vivo pharmacology studies including efficacy, pharmacokinetic and pharmacodynamic endpoint and biomarker studies, as well as provide input into toxicology studies.
    • Develop robust methods to quantitate modulation of target engagement and gene expression, experience with chromatin or histone modification preferred
    • In partnership with Translational Medicine, identify relevant Biomarkers for transition from animal studies to humans.
    • Provide input into the design of translational research studies focusing on patient stratification, and biomarker identification.
    • Contribute to the writing of relevant research reports to be included in regulatory filings.
    • Maintain expertise and awareness in state-of-the-art gene expression modulation platforms and protocols.
    • Ensure CROs are maintaining laboratory notebooks in compliance with Fulcrum Therapeutics policies.
    • Communicate scientific progress to management, advisors, and scientific founders.
    • Prioritize group’s efforts to align with and meet or exceed company goals and timelines.
    • Recruit, train, manage, and retain high-value employees.

    Requirements

    • Ph.D. in neuroscience, genetics, pharmacology or related field with 8+ years of relevant working experience in drug discovery or translational medicine.
    • The ideal candidate will have at least 6+ years of biopharmaceutical industry experience with a focus in neurologic or neuromuscular diseases. Experience in genetically defined Biomarker strategies preferred.
    • Demonstrated experience leading therapeutic programs and the ability to move candidate molecules through the lead selection process.
    • Up-to-date knowledge of gene regulation mechanisms and methods preferred.
    • Experience designing and managing preclinical in vivo pharmacology studies.
    • A demonstrated track record of independent critical thinking and scientific achievement.
    • Experience leading projects and working with cross-functional teams.
    • Must have strong oral and written communication skills.
    • Ability to lead teams in a cross-functional work environment is critical; strong leadership skills and ability to work independently are expected.
  • Computational Biologist

    Description

    We are seeking a highly motivated Scientist or Sr. Scientist to join our efforts at Fulcrum. This individual will focus primarily on next generation sequencing data in conjunction with human or model organism phenotypic data as it relates to our therapeutic programs.

    Responsibilities

    • Analyze genome, epigenome, transcriptome, and proteomic datasets
    • Contribute to experimental study design
    • Involved with therapeutic target and biomarker identification
    • Adjusts to new data and changing project needs

    Requirements

    • An advanced degree or significant experience in computational biology, bioinformatics, molecular biology, computer science/engineering, statistics or related areas
    • Intermediate to advanced programming skills (i.e. Python, R)
    • Experience with high performance computing, preferably on the cloud (i.e. AWS)
    • Experience with open source NGS analysis software, analysis pipelines
    • Experience with Jupyter Notebooks, Github or related tools
    • Knowledge of publicly available databases (i.e. ENCODE, GEO)
    • Familiarity with pathway analysis
    • Good grasp of transcriptional and epigenetic biology; wet lab experience is a plus
    • Good grasp of transcriptional and epigenetic biology; wet lab experience is a plus
    • Evidence of maturity, resourcefulness, and leadership potential
    • Team oriented, highly collaborative
    • Excellent oral and written communication skills, fluency in English
  • Data Scientist – Machine Learning and Statistics

    Description

    We’re seeking a highly motivated individual at the Scientist or Sr. Scientist level to join our efforts at Fulcrum. This position will focus primarily on next generation sequencing data in conjunction with human or model organism phenotypic data as it relates to our therapeutic programs.

    Responsibilities

    • This position will focus on the development and application of statistical methods for the integrated analysis of large­scale bioinformatics datasets
    • Has experience with a wide array of machine learning algorithms and data mining methods (i.e. time series analysis, state space models, adaptive filtering, mixed effect models, hierarchical Bayes, Markov models, decision trees, boosting, random forests, support vector machines)
    • Perform exploratory data analysis of very large datasets from varying sources, draw inferences and insights to design or tune statistical models/learning algorithms for identifying genes predictive of phenotypes or clinical outcomes.
    • Evaluate fits, error metrics and model diagnostics to assess and improve model performance.
    • Curate large molecular and phenotypic datasets.
    • Interpret analysis to a broad array of wet lab scientists.

    Requirements

    • An advanced degree in a relevant technical field (i.e. Bioinformatics, Statistics, Computer Science, Engineering, Physics, Math, Finance)
    • Intermediate to advanced programming skills (i.e. Python, C++, Scala)
    • Expert knowledge of a statistical analysis package (i.e. R, Matlab, SAS)
    • Experience with high performance computing, preferably on the cloud (i.e. AWS)
    • Proficient with data visualization techniques
    • Experience with Hadoop/Map-Reduce/Spark and related tools
    • Good publication record
    • Evidence of maturity, resourcefulness, and leadership potential
    • Prefers team oriented, collaborative work environments
    • Excellent oral and written communication skills, fluency in English

Note to Recruitment Agencies: Please do not forward any agency resumes. Fulcrum Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Equal Opportunity Employer M/F/D/V