Join Us


Fulcrum Therapeutics, a Third Rock portfolio company and Fierce 15 award winner, is looking for exceptional individuals who share our passion to create new medicines to deliver a new future for patients and their families by unlocking gene regulation in disease.
At Fulcrum, we are dedicated to our patients, who desperately need breakthrough medicines. And we proudly support our employees as we work to achieve our shared goal of making a positive difference in patients’ lives. We are both shepherds of your career, and your biggest champions.
Our culture celebrates innovation and excellence.  If you want to experience being part of a team committed to delivering revolutionary science to patients in need of new treatment options, we invite you to learn more about our core values and explore Fulcrum’s career opportunities.
We offer a stimulating environment, tremendous growth opportunities as well as a comprehensive compensation and benefits package.


Core Values

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Open Positions


To be considered for an opportunity at Fulcrum Therapeutics, please submit your CV with the title of the position in the subject line to

  • Senior Scientist, Medicinal Chemistry


    We are seeking a highly motivated medicinal chemist to be responsible for the design of small-molecule drug candidates in target validation, hit-to-lead and lead optimization projects in collaboration with external CROs. The successful candidate must have a demonstrated ability to innovate across the full spectrum of medicinal chemistry projects. In addition, he/she will engage in synthetic and medicinal chemistry problem solving and work with team members across disciplines to analyze diverse data sets to build structure-activity relationships and drive programs. As a Senior Scientist, the successful candidate will have collaborative engagement with the external scientific community and make direct contributions to Fulcrum’s external reputation.


    • Lead the external execution of design, synthesis, purification and characterization of bioactive compounds
    • Facilitate the design of new bioactive compounds by interacting with other chemists and biologists to optimize DMPK, in vitro, and in vivo pharmacology properties.
    • Lead and oversee effective interactions with external CROs.
    • Monitor and evaluate tasks to meet project time frames.


    • PhD in synthetic organic chemistry or equivalent.
    • Structure-based drug design experience preferred.
    • At least 5-10 years of industry experience strongly preferred.
    • High level of creativity and productivity with strong synthetic chemistry problem solving skills.
    • Demonstrated excellence in organic synthesis, conversant with the current literature.
    • Ability to champion chemistry efforts into new directions to achieve project milestones.
    • Strong evidence of conceptual thinking, active follow-through and vigorous scientific curiosity.
    • Proven ability to work well with others in a dynamic and highly collaborative environment.
    • Exceptional interpersonal, verbal and written communication skills.
  • Computational Biologist


    We are seeking a highly motivated Scientist or Sr. Scientist to join our efforts at Fulcrum. This individual will focus primarily on next generation sequencing data in conjunction with human or model organism phenotypic data as it relates to our therapeutic programs.


    • Analyze genome, epigenome, transcriptome, and proteomic datasets
    • Contribute to experimental study design
    • Involved with therapeutic target and biomarker identification
    • Adjusts to new data and changing project needs


    • An advanced degree or significant experience in computational biology, bioinformatics, molecular biology, computer science/engineering, statistics or related areas
    • Intermediate to advanced programming skills (i.e. Python, R)
    • Experience with high performance computing, preferably on the cloud (i.e. AWS)
    • Experience with open source NGS analysis software, analysis pipelines
    • Experience with Jupyter Notebooks, Github or related tools
    • Knowledge of publicly available databases (i.e. ENCODE, GEO)
    • Familiarity with pathway analysis
    • Good grasp of transcriptional and epigenetic biology; wet lab experience is a plus
    • Good grasp of transcriptional and epigenetic biology; wet lab experience is a plus
    • Evidence of maturity, resourcefulness, and leadership potential
    • Team oriented, highly collaborative
    • Excellent oral and written communication skills, fluency in English
  • Director Level – Business Development

    Position Overview & Responsibilities

    The Associate Director/Director of Business Development will drive Fulcrum’s business development activities, as well as support strategy, and alliance management functions.


    • Source and screen potential licensing opportunities, coordinating due diligence, term sheets, negotiation, contracting, and decision-making.
    • Contribute to and execute a comprehensive non-dilutive revenue strategy for Fulcrum, including industry partnerships, government grants, lobbying, and outreach to foundations and patient advocacy groups.
    • Support partnering activities, including preparing pitch decks, term sheets, and other materials as needed to support negotiations and diligence activities.
    • Provide analytic support by conducting product/market forecasts, NPV valuations, and other financial analyses as needed in support of R&D and corporate business decisions.
    • Coordinate Fulcrum scientists, legal and administrative staff, and external legal firms to manage workflow in delivering academic/industry collaborations (SRAs, MTAs, CDAs, etc.).
    • In conjunction with IP/legal/finance leadership at Fulcrum, manage fulfillment of contractual obligations, including reporting, payments, and compliance.
    • Manage non-standard contracts including with scientific/medical advisors, and other vendors.


    • BA/BS required; MBA plus graduate degree in scientific / medical discipline (Ph.D. or M.D.) strongly preferred.
    • 5+ years biopharmaceutical experience; candidates with industry, as well as relevant investment banking and consulting backgrounds, will be considered.
    • High energy individual with a positive “nothing is impossible” attitude.
    • Ability to work in a hands-on collaborative fashion with many different disciplines both inside and outside of the company.
    • Strong knowledge of biotechnology industry, drug discovery and development process.
    • Ability to work independently in an entrepreneurial, matrixed environment.
    • Ability to multi-task and prioritize to manage multiple projects simultaneously.
    • Ability to perform mathematical modeling including calculations such as NPV and product forecasting.
    • Experience with commercial and scientific assessment of new product opportunities.
    • Proficiency in speaking, comprehending, reading and writing English is required. Ability to read and interpret comprehensive and intricate research documents. Ability to write scientific reports and technical correspondence. Ability to work with executives and communicate abstract concepts. Ability to present to a high level of the organization and groups outside of the organization.
    • Periodic travel may be required

Note to Recruitment Agencies: Please do not forward any agency resumes. Fulcrum Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Equal Opportunity Employer M/F/D/V

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