Join Us


Fulcrum Therapeutics, a Third Rock portfolio company and Fierce 15 award winner, is looking for exceptional individuals who share our passion to create new medicines to deliver a new future for patients and their families by unlocking gene regulation in disease.
At Fulcrum, we are dedicated to our patients, who desperately need breakthrough medicines. And we proudly support our employees as we work to achieve our shared goal of making a positive difference in patients’ lives. We are both shepherds of your career, and your biggest champions.
Our culture celebrates innovation and excellence.  If you want to experience being part of a team committed to delivering revolutionary science to patients in need of new treatment options, we invite you to learn more about our core values and explore Fulcrum’s career opportunities.
We offer a stimulating environment, tremendous growth opportunities as well as a comprehensive compensation and benefits package.


Core Values

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Open Positions


To be considered for an opportunity at Fulcrum Therapeutics, please submit your CV with the title of the position in the subject line to

  • Principal/Senior Scientist – Biomarker & Translational Medicine


    We’re seeking a highly motivated and technically excellent laboratory Scientist with a strong background in disease characterization and biomarker discovery to join our Translational Medicine Department to contribute to building our discovery pipeline for monogenic neuromuscular diseases. The successful candidate will focus on the discovery and progression of novel biomarkers and therapeutics for Fulcrum programs. Responsibilities include leading scientific research to identify, evaluate, and characterize relevant blood, CSF, and other tissue-based biomarkers that will provide pharmacodynamic and efficacy endpoints in preclinical and clinical settings.


    • Develop strategy and scientific approach to identify novel diagnostic, prognostic, and pharmacodynamic biomarkers to enable go/no go decisions for programs to assist in program progression.
    • Develop in vitro and biochemical assays to evaluate efficacy, PK/PD relationship, and novel biomarkers to characterize molecules for potential therapeutic effects.
    • Lead the identification and validation of novel biomarkers to enable go/no go decisions for programs to assist in program progression.
    • Establish and manage external research collaborations to identify diagnostic and prognostic biomarkers of neuromuscular and other monogenic diseases (Fragile X, FSHD and others)
    • Participate in and lead cross-functional teams to support preclinical drug discovery and development.
    • Prepare, review and deliver high quality scientific presentations for internal/external use.
    • Commit to help the team achieve deliverables and meet aggressive timelines.


    • M.S. / PhD with at least 6 years post-degree research in an industry setting.
    • Extensive experience in cellular and biochemical science such as standard molecular biology and protein biochemistry techniques (e.g. cell culture, immunohistochemistry, protein purification, real-time PCR, protein quantification, immunoprecipitation) is required.
    • Strong publication record and demonstrated experience conducting independent research, preferably in the field of muscle diseases
    • Hands on experience in the development and validation of biomarker assays in the preclinical and clinical setting required.
    • Strong leadership and evidence of strategic scientific thinking.
    • Expertise in cutting edge assay technologies and proven assay troubleshooting skills.
    • Proven ability to deliver high quality and validated biomarkers to first in human studies considered a strong plus
  • Scientist/Senior Scientist, In Vivo Pharmacology


    Fulcrum Therapeutics is pioneering small molecule therapeutic approaches to gene regulation in genetically defined diseases. The current opening is for a Scientist or Senior Scientist within the fast-paced, innovative, in vivo pharmacology team.

    Essential Areas of Responsibility:

    The successful candidate will independently design, execute and interpret mechanistic in-vivo pharmacology research projects in the areas of genetically defined central nervous system (CNS) and musculoskeletal disorders. The candidate will participate as part of a multi-disciplinary team to conduct experiments aimed at building relationships between pharmacokinetic and pharmacodynamic effects of potential drug candidates in support of non-clinical drug discovery. In addition to their lab-based responsibilities, the candidate will be responsible for: 1) maintaining a working knowledge of current experimental techniques and literature in their scientific specialty; 2) designing innovative research studies to support discovery of development candidates and generation of intellectual property; 3) contributing to and leading discovery project team activities; 4) presenting scientific data internally and at scientific conferences; 5) authoring study reports, regulatory documents and scientific manuscripts; and 6) managing external research collaborations and engagement with scientific advisors and consultants. The person in this position will be expected to work collaboratively with others across multiple disciplines.


    • Design, execution and analysis of in-vivo and ex-vivo pharmacology studies using innovative rodent models of CNS and musculoskeletal disorders. Responsibilities include rodent handling, drug delivery via multiple routes of administration (IV, SC, ICV, PO), necropsy, sample collection, behavioral analyses, statistical analysis, etc.
    • Execution of studies aimed at building pharmacologic relationships between drug exposure, target engagement, pharmacodynamic biomarkers and disease protein gene expression in rodents.
    • Develop robust assay methods to quantify disease target gene expression modulation, and chromatin or histone modification in normal or diseased tissue, blood and/or CSF. Studies involve engraftment of novel human neural precursor cells into the CNS to build relevant disease models.
    • Develop robust assay methods to measure pharmacodynamic protein endpoints in normal or diseased tissue, blood and/or CSF.
    • Perform mechanistic pharmacology studies using genetic techniques including CRISPR, RNAi/shRNA, ASO, etc.
    • Collaborate effectively with colleagues from in vitro biology, in vivo biology and translational medicine teams to execute responsibilities.
    • Coordinate with CROs to design, execute and analyze the data from the aforementioned in vivo experiments.


    • Ph.D (with 3+ years of post-doctoral or industry experience), MS (with 5+ years of equivalent experience) or BS/BA (with 8+ years of equivalent experience).
    • Extensive experience with rodent handling, drug administration and expertise with ex-vivo techniques (such as RT-PCR, ELISA, protein analysis via western blot, WES, and/or MSD) allowing for mechanistic interrogation of models of CNS and musculoskeletal disorders is necessary.
    • Hands-on experience performing small animal surgeries (including catheterization, osmotic pump implantation and intra-cranial device implantation).
    • Demonstrated ability to thrive in team environment.
    • Strong experimental background and ability to bring a rigorous, analytical approach to problem solving.
    • Excellent presentation and oral/written communication skills applied to technical study reports, notebook organization, manuscript preparation and statistical applications. Maintenance of laboratory notebooks in compliance with Fulcrum Therapeutics policies.
    • Experience working on cross-functional drug discovery project teams is preferred.
    • Preference will be given to candidates with experience performing small animal surgeries and a background in CNS related rare diseases and/or muscle cell biology.
    • The successful candidate will have outstanding initiative, be highly motivated to drive our science forward, learn new techniques and procedures, and be able to effectively conceive and execute complex mechanistic studies in diverse diseases.
  • Accounting Manager


    The company aspires to advance its discovery platforms, ultimately bringing forth clinical candidates. Financing these goals, will involve significant fundraising events in 2018 in the form of a Series B round and a Partnership. This position will report directly into the VP, Finance & Accounting and will participate cross functionally with all member’s finance team under the CFO’s leadership.


    • Perform transactional accounting duties: payroll processing; accounts payable; cash reconciliations
    • Field, triage and resolve daily employee issues as they pertain to financial processes
    • Perform monthly close including improving quality of current close activities. Prepare all account reconciliations and GAAP basis financial reporting; GL maintenance
    • Teaming with VP, Finance and Accounting the goal will be to document financial infrastructure and processes as they currently exist and then recommend and implement process improvements
    • Be main point of contact for organization with respect to questions pertaining to: purchasing processes; time reporting; payments; other ad-hoc queries
    • Prepare audit work papers including all balance sheet roll forward schedules and key P and L and operations schedules; pull and organize all supporting documentation
    • Serve as key contact with auditors to: obtain audit selections, documentation and respond to auditor queries regarding such


    • The ideal candidate will have 5 plus years’ accounting experience, including supervisory and audit experience, CPA preferred. In addition, this person needs to perform both as an individual contributor and manage/coordinate the output and activities of other finance team members. Life Science experience and public accounting experience are ideal.
  • Summer Intern: Computational Biology and Machine Learning


    If you have interest in computational biology, machine learning, and drug development, Fulcrum Therapeutics is providing an opportunity to intern with the Computational Biology team this summer. This is a chance to learn about applying machine learning approaches to drug development research in rare neuronal/neuromuscular diseases such as Fragile X Syndrome and muscular dystrophies. The project will focus on mining and making data-driven predictions on molecular profiling and genomics data from these diseases.


    • Establish data mining algorithms and software to prioritize novel drug targets
    • Curate public and internal datasets
    • Report on findings and relevant code


    • Advanced undergraduate or entry-level masters student in biological sciences, computer science/engineering or related fields in a U.S.-based accredited institution
    • Strong practical experience with a modern OOP language (i.e. Python, Java, etc)
    • Familiarity with statistical analysis and related software tools (i.e. R, Matlab, etc)
    • Exposure to Data Science coursework is a bonus
    • Ability to clearly communicate verbally and in written format using English
    • Evidence of maturity and resourcefulness
    • 1-2 letters of recommendation from university faculty or related staff

Note to Recruitment Agencies: Please do not forward any agency resumes. Fulcrum Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Equal Opportunity Employer M/F/D/V

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