Join Us

 

Fulcrum Therapeutics, a Third Rock portfolio company and Fierce 15 award winner, is looking for exceptional individuals who share our passion to create new medicines to deliver a new future for patients and their families by unlocking gene regulation in disease.
 
At Fulcrum, we are dedicated to our patients, who desperately need breakthrough medicines. And we proudly support our employees as we work to achieve our shared goal of making a positive difference in patients’ lives. We are both shepherds of your career, and your biggest champions.
 
Our culture celebrates innovation and excellence.  If you want to experience being part of a team committed to delivering revolutionary science to patients in need of new treatment options, we invite you to learn more about our core values and explore Fulcrum’s career opportunities.
 
We offer a stimulating environment, tremendous growth opportunities as well as a comprehensive compensation and benefits package.

 

Core Values

 
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Open Positions

 

To be considered for an opportunity at Fulcrum Therapeutics, please submit your CV with the title of the position in the subject line to careers@fulcrumtx.com.

Note to Recruitment Agencies: Please do not forward any agency resumes. Fulcrum Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Equal Opportunity Employer M/F/D/V

  • Senior Director, Biology

    Description

    The successful candidate will play a key role shaping the future of Fulcrum Therapeutics by helping lead the Biology Team to identify and enable targets through the design of robust gene and protein expression assays or identified computationally using innovative primary and iPS cell derived cell models from patients with genetically defined central nervous system (CNS) and musculoskeletal disorders. The candidate will be responsible for a talented team of creative scientists that will leverage state-of-the-art CRISPR genomic and small molecule phenotypic screening in a highly automation leveraged HTS environment. This leader will need to work across an excellent multi-disciplinary team to enable targets for small molecule drug discovery and lead the team to generate decisional, statistically robust in vitro pharmacology data to inform an innovative design chemistry team. In this leadership role, the successful candidate will be responsible for enablement of drug discovery targets with generation of intellectual property, leading discovery project team activities, presenting scientific data internally and externally, authoring study reports with regulatory documentation, contributing to high impact scientific manuscripts, identifying & managing external research collaborations, and engaging with scientific advisors and founders. In this position, this leader will be expected to work collaboratively with others across multiple disciplines while mentoring a growing team and supporting Fulcrum’s culture and core values.

    Responsibilities

    • Lead the Biology team to design, execute and build quality-controlled target discovery assays and conduct in-vitro pharmacology studies using innovative human models of CNS and musculoskeletal disorders. Responsibilities include rigorous statistical analysis, data reporting, data visualization, etc.
    • Ensure execution of studies aimed at building pharmacologic relationships between drug concentration, target engagement, pharmacodynamic markers and disease protein gene expression in human cell models of neuromuscular disease.
    • Propose new programs/diseases/areas of science that could be considered for future portfolio expansion
    • Lead team to perform target mediated mechanistic and pharmacology studies using genetic techniques including CRISPR, RNAi/shRNA, ASO, etc. in collaboration with a matrixed team of computational scientists, cell biologists, transcriptional biologists, physiologists, in vivo pharmacologists, and translational biomarker team members.
    • Coordinate with collaborators and CROs, as needed, to manage in vitro experiments and set clear goals and expectations for the broader team.
    • Mentors and develops individual talent capable of taking on future leadership roles. Supports an overall group culture that is agile, proactive, collaborative, and innovative.

    Qualifications

    • Ph.D (with 15+ years of drug discovery industry experience) in genetics, molecular biology, or neuroscience and track record of supervisory experience.
    • Track record delivering validated drug discovery targets using CRISPR genomic and small molecule phenotypic screen. Experience with primary or iPSC- derived neurons and myotubes would be an advantage.
    • Extensive experience leading a team to develop statistically robust cell-based assays to support small molecule drug discovery, HTS experience, quantitative immunocytochemistry and analysis, excellent HTS statistical or image analysis algorithms and data analytics allowing for mechanistic interrogation of small molecule pharmacology in CNS and musculoskeletal disorders is necessary.
    • Extremely effective project team leader, supervisor and mentor in a matrixed environment that can motivate a high functioning team of scientists to cultivate critical path thinking and agility in drug discovery.
    • Experienced team leader who effectively manages external collaborations and service providers and ability to bring pragmatic business minded approach to balancing internal and external capabilities.
    • Professionally represents the group and company more broadly in collaborations, partnership discussions, external relationships and conferences.
    • Proven track record of scientific contributions in target discovery using genomic and small molecule screening as evidenced by quality and quantity of publications/ presentations/ inventions and clinical candidates.
    • Highly motivated cross-functional team player who is flexible with ability to work in a fast-paced environment. Ability to provide novel, innovative solutions to challenging problems. Desire to learn and tackle new challenges and initiatives. Possess an extremely high degree of scientific discretion, intuition and integrity.
    • Strong written and oral communication is a requirement to support internal and external communication of data, intellectual property filings, study reports and regulatory documentation.
    • Excellent teamwork in a highly matrixed environment with ability to mentor, grow leaders and maintain focus on Fulcrum’s culture and values.
  • Director, Corporate Strategy/New Product Planning

    Description

    Reporting to the Chief Operations Officer, the Director of Strategy will be an integral part the company’s growth strategy. This role, in partnership with the leadership team and functional areas, will help guide strategic decision making around the company’s product engine. This position offers the opportunity to significantly contribute to the long-term success of the portfolio and is responsible for generating a strategic framework to inform the company’s focus and pipeline.

    Responsibilities

    • Work with leadership team to develop strategic framework to make decisions regarding prioritization with therapeutics areas and disease states of interest.
    • Understand disease biology, mechanism of potential intervention, current treatment paradigms and competitive landscape to make decisions regarding potential clinical programs
    • Lead initiatives to continually assess the commercial values, competitive landscapes and market differentiations (incorporating KOL advice) of the early assets and develop and communicate Commercial priorities for resource allocation and decision making
    • Implement new disease selection and decision-making process for company’s discovery initiatives
    • Work with clinical team to devise potential clinical strategies
    • Develop life-cycle strategy and additional indications for clinical candidates
    • Manage external consulting partners (e.g., strategy consultants, market research), to update commercial assessment tool(s) as needed and proactively seek out ways to improve assessments
    • Track and understand the therapeutic market trends from a commercial, managed markets, clinical, and scientific perspective and stay up to date in market developments and changes in competitive landscape for key therapeutic

    Qualifications

    • Advanced scientific degree required (PhD, MD)
    • 5+ years’ experience with market research and/or marketing analytics, strategic consulting, or biotech investment fund
    • Experience working in or with early stage biotech companies
    • Significant analytic skills, able to clearly interpret and distill scientific, clinical and commercial information
    • Develop framework to make decisions amongst clinical programs, disease states, therapeutic areas based on science, clinical data, commercial opportunity and patient needs
    • Ability to quickly gain deep understanding of disease biology and translate into research and clinical development decisions
    • Ability to work, influence, and gain consensus across multiple functions
    • Excellent organization, communication (written and oral) and facilitation skills
    • Self-motivated, builds trust easily and operates with integrity and ethics
    • Demonstrated learning agility
  • Principal Scientist, In Vivo Pharmacology

    Description

    The successful candidate will independently design, execute and interpret mechanistic in-vivo pharmacology research projects in the areas of genetically defined central nervous system (CNS) and musculoskeletal disorders. The candidate will participate as part of a multi-disciplinary team to conduct experiments aimed at building relationships between pharmacokinetic and pharmacodynamic effects of potential drug candidates in support of non-clinical drug discovery. In addition to their lab-based responsibilities, the candidate will be responsible for: 1) maintaining a working knowledge of current experimental techniques and literature in their scientific specialty; 2) designing innovative research studies to support discovery of development candidates and generation of intellectual property; 3) contributing to and leading discovery activities; 4) presenting scientific data internally and at scientific conferences; 5) authoring study reports, regulatory documents and scientific manuscripts; and 6) managing external research collaborations and engagement with scientific advisors and consultants. We are looking for experienced candidates to join our multidisciplinary team in an exciting and dynamic R&D environment.

    Responsibilities

    • Design, execution and analysis of in-vivo and ex-vivo pharmacology studies using innovative rodent models of CNS and musculoskeletal disorders. Responsibilities include rodent handling, drug delivery via multiple routes of administration (IV, SC, ICV, PO), necropsy, sample collection, behavioral analyses, statistical analysis, etc.
    • Design and assist in execution of studies aimed at building pharmacologic relationships between drug exposure, target engagement, pharmacodynamic biomarkers and disease protein gene expression in rodents.
    • Develop robust assay methods to quantify disease target gene expression modulation, and chromatin or histone modification in normal or diseased tissue, blood and/or CSF. Studies may involve the engraftment of human cells into rodent tissues in order to build relevant models for PK/PD relationships.
    • Develop robust assay methods to measure pharmacodynamic protein endpoints in normal or diseased tissue, blood and/or CSF.
    • Design and manage preclinical in vivo pharmacology studies including efficacy, pharmacokinetic and pharmacodynamic endpoint and biomarker studies, as well as provide input into toxicology studies.
    • In partnership with Translational Medicine, identify relevant Biomarkers for transition from animal studies to humans.
    • Perform mechanistic pharmacology studies using genetic techniques including CRISPR, RNAi/shRNA, ASO, etc.
    • Collaborate effectively with colleagues from in vitro biology, in vivo biology, translational medicine and chemistry teams to execute responsibilities.
    • Coordinate with CROs to design, execute and analyze the data from the aforementioned in vivo experiments.
    • Communicate scientific progress to management, advisors, and scientific stakeholders.
    • Recruit, train, manage, and retain high-value employees.

    Qualifications

    • Ph.D (with 7+ years of post-doctoral and industry experience), MS (with 10+ years of equivalent experience) or BS/BA (with 12+ years of equivalent experience).
    • Extensive experience with rodent handling, drug administration and expertise with ex-vivo techniques (such as RT-PCR, ELISA, protein analysis via western blot, WES, and/or MSD) allowing for mechanistic interrogation of models of CNS and musculoskeletal disorders is necessary.
    • Hands-on experience performing small animal surgeries (including catheterization, osmotic pump implantation and intra-cranial device implantation).
    • Demonstrated ability to thrive in team environment.
    • Strong experimental background and ability to bring a rigorous, analytical approach to problem solving.
    • Excellent presentation and oral/written communication skills applied to technical study reports, notebook organization, manuscript preparation and statistical applications. Maintenance of laboratory notebooks in compliance with Fulcrum Therapeutics policies.
    • Experience working on cross-functional drug discovery project teams is preferred.
    • Preference will be given to candidates with experience performing small animal surgeries and a background in CNS related rare diseases and/or muscle cell biology.
    • The successful candidate will have outstanding initiative, be highly motivated to drive our science forward, learn new techniques and procedures, and be able to effectively conceive and execute complex mechanistic studies in diverse diseases.
  • Bioinformatics Engineer

    Essential Areas of Responsibility

    Fulcrum is seeking a Bioinformatics Engineer to (1) implement and manage lab informatics software applications utilized across research teams and (2) build and sustain custom software in the Computational Biology group. Lab informatics includes applications such as GeneData, Dotmatics, LIMS-biorepository systems, cheminformatics tools, and relational databases. Working closely with the IT/Operations and Molecular Sciences groups at Fulcrum, this individual will manage these applications on the cloud in a secure manner, serve as the point of contact with application vendors, organize training, and operate on an efficient budget. Custom software development within Computational Biology will be focused on, but not limited to, molecular profiling pipelines.

    Qualifications

    • Bachelors degree in an engineering discipline and/or molecular biology, chemistry with appropriate informatics experience
    • 1+ years of experience managing and implementing informatics and IT solutions, preferably in a biotech or pharma environment
    • Significant coding/development experience in a modern OOP language (i.e. Python)
    • Experience with Linux, Windows command line admin tools (i.e. bash)
    • Experience with cloud computing (i.e. AWS, Azure, GCP)
    • Experience working in cross-functional teams
    • Experience in successfully implementing, utilizing and leveraging outsourcing and vendor strategies
    • Practical understanding of relational database design and development
    • Excellent communication skills and customer-focus
    • Written and spoken fluency in English
    • Team player comfortable in a fast-moving startup environment
    • Evidence of maturity and a “can do” spirit
  • Computational Biologist

    Description

    We are seeking a highly motivated computational biologist (open to all experience levels) to join our drug discovery efforts at Fulcrum specifically around target and biomarker identification in rare genetic diseases. This individual will focus on understanding molecular profiling data and their relationships to human phenotypic information using bioinformatic and machine learning approaches. The individual will work as part of a tight-knit computational biology group that is matrixed across several different experimental and translational teams.

    Responsibilities

    • Analyze genome, epigenome, and transcriptome datasets
    • Contribute to experimental study design and data interpretation, visualization
    • Expand efforts in single cell technologies
    • Identify, generate, and curate new sources of data

    Qualifications

    • An advanced degree or significant experience in computational biology, bioinformatics, molecular biology, computer science/engineering or related areas
    • Significant experience in regulatory genomics and transcriptomics
    • Familiarity with systems biology, single cell genomics
    • Intermediate to advanced programming skills and good practices preferably in Python, R, Github, Jupyter
    • Experience with high performance computing, preferably on the cloud (i.e. AWS, Azure, GCP)
    • Experience with open source bioinformatics software and pipelines
    • Knowledge of public databases and their access (i.e. ENCODE, GEO)
    • Good publication record
    • Evidence of maturity, resourcefulness, and leadership potential
    • Team-oriented, highly collaborative, proactive
    • Excellent oral and written communication skills, fluency in English
  • Senior IT Infrastructure Engineer

    Description

    We are looking for a hands-on Senior IT Infrastructure Engineer to join our team that builds, maintains, and supports Fulcrum’s corporate IT infrastructure and internal staff. This role is an exciting opportunity to be a critical part of a team that is fueling a growing biotech company. In addition to having a solid technical background, this candidate will have excellent communications skills, be able to work with a managed services provider, and have a passion for service and all things IT. The ideal candidate will have previous experience with or have directly worked in the Life Sciences industry.

    Responsibilties

    The IT team is responsible for help desk support, server administration, IT security, workstations, laptops, network configuration, and Lab IT/Informatics support. It also is responsible for audio/video conference systems, VoIP, file storage systems, and backups. Additionally, the team supports and maintains Fulcrum’s cloud operations in AWS.

    Qualifications

    • 3-5 years IT Operations/Systems administration
    • 1+ years Project Management experience
    • Excellent leadership skills, writing and verbal communications skills
    • Experience working with cross-functional departments and teams
    • Experience with AWS configuration and administration
    • Experience with Network configuration, support and maintenance for servers, workstations, and laptops
    • Experience with VMWare ESXi & Windows, Linux, and Mac Operating Systems
    • Experience with Enterprise Backups, Disaster Recovery, and BDRs.
    • Solid fundamental knowledge of Network protocols such as TCP/IP, HTTP, NTP, SNMP
    • Solid fundamental knowledge of IT Security + Identity and Access Management
    • Experience with Office 365 Administration and Scripting (PowerShell, AWS CLI), and deployment/management tools
    • Bachelors in Computer Science, Information Systems, related field or equivalent demonstrable experience

    Additional Qualifications

    • Teamwork – works well with others within team and across groups in company
    • Execution Success – plans and meets/exceeds objectives on time and with quality
    • Entrepreneurial – flexible, optimistic, problem-solving approach
    • Leadership and Initiative – does the right thing without being asked, proactive at dealing with issues, can-do attitude
  • Senior/Principal Biostatistician

    Description

    We are seeking an experienced Biostatistician to join the team and lead the statistical strategy within the Clinical Development function. This individual would report to the Head of Clinical Development and would be responsible for the biostatistical data management function. Additionally, they will provide statistical input and support to ensure plans and analyses are accurately designed, specified and conducted; and will ensure achievement of statistical deliverables with efficiency and quality.

    Responsibilities

    • Serve as biostatistics leader at Fulcrum and provide internal training to the team as needed.
    • Provide statistical oversight of all research study protocols in the preclinical and clinical space and participate in reviews as needed.
    • Ensure consistency in statistical methods applied to all study designs.
    • Provide detailed review of existing data to inform assumptions for design of clinical trials and to set appropriate assumptions for power calculations.
    • Provide sample size and design proposals for Clinical Trials.
    • Biostatistics project management including but not limited to vendor hiring, vendor management, directing statistical programming, and escalating issues in a timely manner.
    • Be responsible for oversight of data management in outsourced clinical trials.
    • Function as study level statistician for internal studies.
    • Ensure high quality, timely delivery of statistical analysis plans and study tables/listings and statistical reports.
    • Execute quality assurance procedures on work produced by others, ensuring statistical analysis is being done according to specifications.
    • Provide support for publications as needed.
    • Support interactions with Regulatory Agencies on statistical issues and provide solutions as needed.
    • Author or review statistical SOPs, data management SOPs, and Working Instructions.
    • Keep up-to-date with the latest statistical methods development related to clinical trials and attend statistical workshops or seminars.

    Qualifications

    • PH.D. or master’s degree in Biostatistics or applied mathematics.
    • Minimum of 10+ years of industry experience as a Biostatistician in clinical trial.
    • Minimum of 6 years of SAS programming experience
    • Minimum of 3 years of documented regulatory submission support experience (one or more of SAP, submission dossier review, briefing package review, responses to inquiries)
    • Proficiency in statistical programming using SAS and other statistical software
    • Experience in providing vendor oversight
    • Ability to present to management and other groups to clearly communicate statistical thinking and ideas
    • Regulatory interaction experience preferred (pre-NDA, End-of-Phase 2, SPA, Adcom, Audit)
  • Administrative Assistant/Receptionist

    Description

    We are looking for Administrative Assistant/Receptionist to join our team and contribute to an outstanding research organization. This position will be the first point of contact for visitors and will also provide support for several functions in the company, including meeting coordination, operations support, and travel planning. This position requires a high level of customer service within the reception area. The Administrative Assistant will support various department heads & projects, making this a great position for someone looking to learn and development within an early-stage biotech company.

    Responsibilities

    • Greet visitors; maintain tidy, welcoming and presentable reception area
    • Manage the main phone line, answer calls, direct callers, provide assistance and take concise telephone messages
    • Main point of contact for shipping (incoming/outgoing), coordinate scheduling of courier services
    • Coordinate and assist IT with computer presentations, seminars and ID badges for new hires/guests
    • Maintain the inventory for office/kitchen supplies, process weekly orders, ensure areas are well stocked
    • Maintain office telephone extension list and calendar of events
    • Schedule company meetings, recurring/standard meetings, events, etc. Work with meeting owners to reschedule any conflicts and track attendee list
    • Handle all food ordering for the office; organize and order all company lunches and small internal lunch meetings, order weekly groceries
    • Work with maintenance team to make sure office always stays clean and presentable
    • Help set up New Hires; set-up desk and office access, populate calendar, welcome on first day
    • Manage OfficeSpace software; maintain desk count and moves, create maintenance requests
    • Assist other employees with special/ad hoc tasks that may arise from time to time

    Qualifications

    • Must be able to maintain a high degree of confidentiality
    • Proficient knowledge of Microsoft office suite including Word, Excel, Power Point and Outlook
    • Must be reliable, organized and possess multi-tasking abilities
    • Excellent verbal and written communication skills

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