Join Us

 

Fulcrum Therapeutics, a Third Rock portfolio company and Fierce 15 award winner, is looking for exceptional individuals who share our passion to create new medicines to deliver a new future for patients and their families by unlocking gene regulation in disease.
 
At Fulcrum, we are dedicated to our patients, who desperately need breakthrough medicines. And we proudly support our employees as we work to achieve our shared goal of making a positive difference in patients’ lives. We are both shepherds of your career, and your biggest champions.
 
Our culture celebrates innovation and excellence.  If you want to experience being part of a team committed to delivering revolutionary science to patients in need of new treatment options, we invite you to learn more about our core values and explore Fulcrum’s career opportunities.
 
We offer a stimulating environment, tremendous growth opportunities as well as a comprehensive compensation and benefits package.

 

Core Values

 
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Open Positions

 

To be considered for an opportunity at Fulcrum Therapeutics, please submit your CV with the title of the position in the subject line to careers@fulcrumtx.com.

  • Senior Director, Biology: New Target Discovery and in vitro Pharmacology

    Description

    The successful candidate will play a key role at Fulcrum Therapeutics leading the nonclinical toxicology work in support of our drug discovery programs and clinical candidates. The ideal candidate will have extensive experience with the design, execution and interpretation of in vitro and in vivo toxicology studies. The candidate will be responsible for competitive bidding/managing studies and reports with CROs to undertake these studies, and will be accountable for the review, analysis and reporting of the safety pharmacology and toxicology data. This leader will need to work across an excellent multi-disciplinary team to advance programs through the pipeline. The successful candidate will have extensive experience creating regulatory documents (INDs, CTAs, NDAs etc.) and interacting with global regulatory agencies.

    Essential Areas of Responsibility

    • The successful candidate will play a key role shaping the future of Fulcrum Therapeutics by helping lead the Biology Team to identify and enable targets through the design of robust gene and protein expression assays or identified computationally using innovative primary and iPS cell derived cell models from patients with genetically defined central nervous system (CNS) and musculoskeletal disorders. The candidate will be responsible for a talented team of creative scientists that will leverage state-of-the-art CRISPR genomic and small molecule phenotypic screening in a highly automation leveraged HTS environment. This leader will need to work across an excellent multi-disciplinary team to enable targets for small molecule drug discovery and lead the team to generate decisional, statistically robust in vitro pharmacology data to inform an innovative design chemistry team. In this leadership role, the successful candidate will be responsible for enablement of drug discovery targets with generation of intellectual property, leading discovery project team activities, presenting scientific data internally and externally, authoring study reports with regulatory documentation, contributing to high impact scientific manuscripts, identifying & managing external research collaborations, and engaging with scientific advisors and founders. In this position, this leader will be expected to work collaboratively with others across multiple disciplines while mentoring a growing team and supporting Fulcrum’s culture and core values.

    Responsibilities

    • Lead the Biology team to design, execute and build quality-controlled target discovery assays and conduct in-vitro pharmacology studies using innovative human models of CNS and musculoskeletal disorders. Responsibilities include rigorous statistical analysis, data reporting, data visualization, etc.
    • Ensure execution of studies aimed at building pharmacologic relationships between drug concentration, target engagement, pharmacodynamic markers and disease protein gene expression in human cell models of neuromuscular disease.
    • Propose new programs/diseases/areas of science that could be considered for future portfolio expansion.
    • Lead team to perform target mediated mechanistic and pharmacology studies using genetic techniques including CRISPR, RNAi/shRNA, ASO, etc. in collaboration with a matrixed team of computational scientists, cell biologists, transcriptional biologists, physiologists, in vivo pharmacologists, and translational biomarker team members.
    • Coordinate with collaborators and CROs, as needed, to manage in vitro experiments and set clear goals and expectations for the broader team.
    • Strong written and oral communication is a requirement to support internal and external communication of data, intellectual property filings, study reports and regulatory documentation.
    • Excellent teamwork in a highly matrixed environment with ability to mentor, grow leaders and maintain focus on Fulcrum’s culture and values.

    Requirements

    • Ph.D (with 15+ years of drug discovery industry experience) in genetics, molecular biology, or neuroscience and track record of supervisory experience.
    • Track record delivering validated drug discovery targets using CRISPR genomic and small molecule phenotypic screen. Experience with primary or iPSC- derived neurons and myotubes would be an advantage.
    • Extensive experience leading a team to develop statistically robust cell-based assays to support small molecule drug discovery, HTS experience, quantitative immunocytochemistry and analysis, excellent HTS statistical or image analysis algorithms and data analytics allowing for mechanistic interrogation of small molecule pharmacology in CNS and musculoskeletal disorders is necessary.
    • Extremely effective project team leader, supervisor and mentor in a matrixed environment that can motivate a high functioning team of scientists to cultivate critical path thinking and agility in drug discovery.
    • Mentors and develops individual talent capable of taking on future leadership roles. Supports an overall group culture that is agile, proactive, collaborative, and innovative.
    • Experienced team leader who effectively manages external collaborations and service providers and ability to bring pragmatic business minded approach to balancing internal and external capabilities.
    • Professionally represents the group and company more broadly in collaborations, partnership discussions, external relationships and conferences.
    • Proven track record of scientific contributions in target discovery using genomic and small molecule screening as evidenced by quality and quantity of publications/ presentations/ inventions and clinical candidates.
    • Highly motivated cross-functional team player who is flexible with ability to work in a fast-paced environment. Ability to provide novel, innovative solutions to challenging problems. Desire to learn and tackle new challenges and initiatives. Possess an extremely high degree of scientific discretion, intuition and integrity.
  • Director Level, Development Program Manager

    Description

    As the Development Program Manager, you will oversee Fulcrum’s R&D development portfolio and create the company’s global project management and resource capacity planning capability, tools, and metrics in order to enhance the efficiency and effectiveness of Fulcrum’s matrix operating model and support the company’s growth. You will partner closely with Senior Management and Portfolio Leadership to ensure comprehensive pipeline prioritization and program decision making. You will oversee broad program management for development programs and will be responsible for the hands-on management of program operations. You will work collaboratively with the program teams to manage and integrate the diverse R&D of drug development and operational activities through interactions with Research, Molecular Sciences, Translational Medicine, Clinical Operations, Finance, and Business Development, in addition to external vendors and partners. By ensuring the appropriate use of tools and metrics, you will enhance project and program delivery and information dissemination to the business; ultimately aligning program activities with corporate strategy and driving value creation and results.

    Responsibilities

    • Champion and lead Development Operations for advanced Programs with a focus on cross-functional and vendor integration
    • Develop and manage cross-functional strategies, plans, and activities from IND enabling through commercialization
    • Lead program-specific Strategic Team and Development Core Team meetings, including agenda development and prioritization and summary authoring
    • Partner closely with Functional Heads, aligned Scientific Team Lead(s), and cross-functional team members to define and track program goals and drive accountability
    • Partner with Finance and Functional Heads to provide program budget and resource oversight (reporting, planning, etc.)
    • Integrate and manage cross-functional vendors and CRO oversight
    • Maintain and coordinate cross-functional timelines, dashboards, and Gantt charts, including tracking milestones/accomplishments and identification of risks and development of associated leadership/team communications
    • Coordinate and lead authoring and maintenance of Strategic Program Plans (SPP) and Target Product Profiles (TPP)
    • Establish and oversee appropriate document management standards (Reports, submissions, technology, etc.) – QC/QA
    • Lead Alliance Management efforts (if partnered Program)
    • Oversee IP Strategy development and management
    • Plan and execute Patient Community Engagement strategies, activities, sponsorships, and relationships

    Qualifications

    • BS/BA, Advanced degree preferred
    • 10+ years’ experience in life sciences industry, with 8+ years of demonstrated program management experience managing cross-functional product development efforts

    Knowledge, Skills and Abilities

    • Demonstrated project management skills; must have high degree of energy, accuracy and attention to detail
    • Ability to thrive in a fast-paced, innovative and dynamic environment while remaining flexible, proactive, resourceful and efficient are essential
    • Ability to work independently and successfully in a matrix environment, and to prioritize and manage multiple tasks simultaneously
    • Ability to integrate and influence cross-functional issues, balance competing priorities effectively, and successfully negotiate desired outcomes
    • Excellent analytical and organizational skills (resources, timelines, cost/risk/benefit analysis)
    • Strong communication skills and fluency with project management tools (Microsoft Project, Excel, PPT presentations, writing, etc.)
    • Outstanding leadership skills and demonstrated passion for creating new medicines, including excellent verbal and written communication skills, an innovative approach to problem-solving, and an integrated view of business and scientific issues
  • Senior Scientist, Cellular Biology

    Description

    We are seeking a highly motivated senior scientist to join our efforts in the Biology Department at Fulcrum to contribute to building our discovery pipeline for CNS diseases. This individual will contribute to scientific efforts focused on building a relationship between gene expression correction and functional improvement of disease phenotypes in complex human cellular models.

    Responsibilities

    • Design, develop and execute human iPSC-derived cell culture models of CNS diseases to identify functional phenotypes through high-content imaging and MEA electrophysiology assays. Analyze complex data sets and clearly communicate results to the larger group.
    • Provide expertise in neurobiology and neurophysiology through a deep understanding of neurodegenerative disorders, synaptic function and signal transduction pathways.
    • Actively participate across functional groups and programs to provide knowledge of molecular, biochemical and pharmacologic techniques required to examine target expression, modulation and function

    Preferred Skills

    • Experience in whole cell patch clamp techniques in either clonal or primary cultured cells, including neurons and myocytes
    • An understanding of theory and application of molecular biology assays to examine gene expression, subcellular localization, fluorescent microscopy techniques and quantitative image analysis
    • Proficiency in development of optical and image-based assay approaches and software for analysis of electrophysiologic experiments is desired (ie. MATLAB). Ability to identify and solve technical issues that arise with imaging and/or electrophysiology equipment
    • Skilled in pharmacologic assessment of both small molecules and other therapeutic modalities in primary or stem cell derived cellular systems
    • Qualifications

      • Ph.D. with at least 4+ year of relevant post-graduate and / or industry experience in neurologic and/ or muscle and/ or cardiovascular diseases
      • Strong oral and written communication skills and a desire to work in a team environment are essential
  • Senior Scientist, Target Validation & Gene Regulation

    Description

    As a Senior Scientist, you will be expected to work equally well in self-starting mode as well as a member of a matrixed team within Fulcrum. Your initial focus will be to develop, implement and execute appropriate in vitro assays required for the advancement of high priority projects. You will work in close collaboration with the management team and scientists to drive our pre-clinical target discovery program and industrialize target validation in a variety of diseases. This role is seeking an individual who desires to learn and tackle new challenges and initiatives and have a direct impact on progressing novel therapies to patients.

    Responsibilities

    • Develop and execute appropriate in vitro assays required for the advancement of high priority projects
    • Work closely with the research team to validate, invalidate and prioritize targets in specific monogenic diseases
    • Industrialize CRISPR-based target discovery approaches in challenging disease models
    • Present and discuss results with the research team and the external research community; work among a team of talented scientists
    • Provide novel, innovative solutions to challenging problems
    • Prepare protocols and SOPs for diverse assays
    • Maintain accurate documentation of experiments
    • Interact and communicate results and conclusions within the biology group and cross functional project teams
    • Review the scientific literature to remain abreast of developments in relevant fields

    Qualifications

    • Ph.D. with at least 4+ year of relevant post-graduate and / or industry experience in neurologic and/ or muscle and/ or cardiovascular diseases.
    • Independently design, execute, troubleshoot, and interpret biological experiments in support of program objectives
    • Track record using genomic approaches, including RNA-seq, ChIP-seq, or ATAC-seq, to understand cellular gene regulatory networks. Experience working closely with computational biologists is a plus
    • Experience using laboratory automation and robotics
    • Expertise in in vitro (cell lines, stem cells and explants) models relevant to skeletal muscle, cardiomyopathy, and / or CNS indications with a proven track record in assay development, implementation and execution
    • Familiarity with muscle cell biology and / or neuroanatomy, knowledge of cellular physiology, electrophysiology and neuro-muscular function, neuro-muscular cell imaging and quantitative algorithm application, and neuro- muscular histopathology is a plus
  • Research Associate, Target Validation and Gene Regulation

    Description

    As a Research Associate, you will be expected to work equally well in self-starting mode as well as a member of a matrixed team within Fulcrum. Your initial focus will be to develop, implement and execute appropriate in vitro assays required for the advancement of high priority projects. You will work in close collaboration with the scientists to drive our pre-clinical target discovery program and industrialize target validation in a variety of diseases. This role is seeking an individual who desires to learn and tackle new challenges and initiatives and have a direct impact on progressing novel therapies to patients.

    Responsibilities

    • Help design, execute, troubleshoot, and interpret biological experiments in support of program objectives
    • Prepare protocols and SOPs for diverse assays
    • Maintain accurate documentation of experiments
    • Interact and communicate results and conclusions within the biology group
    • Develop and execute appropriate in vitro assays required for the advancement of high priority projects
    • Work closely with the research team to validate, invalidate and prioritize targets in specific monogenic diseases
    • Industrialize CRISPR-based target discovery approaches in challenging disease models
    • Discuss results with the research team; work among a team of talented scientists

    Qualifications

    • BS or MS in pharmacology, biology, molecular and/or cellular biology, or a related field
    • At least 3 years of hands-on experience with human primary or iPS-derived cell models, muscle and/ or neuronal cell culture, image-based analysis, gene expression analysis, ELISA, protein analysis, and general molecular biology techniques
    • Experience with using knockdown or over-expression techniques in in vitro models including CRISPR, shRNA, ASO or lentiviral overexpression along with chemical probes to validate or invalidate disease targets
    • Demonstrated ability to thrive in a team environment
    • Strong experimental background and bring a rigorous, analytical approach to problem solving
    • Experience using laboratory automation and robotics
    • Expertise in in vitro (cell lines, stem cells and explants) models relevant to skeletal muscle, cardiomyopathy, and / or CNS indications with a proven track record in assay development, implementation and execution
    • Familiarity with muscle cell biology and / or neuroanatomy, knowledge of cellular physiology, electrophysiology and neuro-muscular function, neuro-muscular cell imaging and quantitative algorithm application, and neuro- muscular histopathology is a plus

Note to Recruitment Agencies: Please do not forward any agency resumes. Fulcrum Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Equal Opportunity Employer M/F/D/V

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