Our core values define us

T.H.I.S. is Fulcrum! And we are the #FULcrew.

From the moment you enter our offices, you’ll be struck by the energy and enthusiasm you see all around you. We have a clear set of values that unite us:

Team work
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Above all else, we are champions for our patients.



In addition to our values, there are five reasons
why Fulcrum might be right for you.


We take great pride in being PURPOSEFUL PATIENT PARTNERS. We don’t just do this for patients, we do it with patients. We partner with patient advocacy organizations and through them we consult with patients on trial design, education and outreach and what we think our data means. We’re in this for one thing. We want to, no we must, give those facing rare diseases something to cheer about!


There is nothing superficial about Fulcrum. We have a culture of TRUST AND TRANSPARENCY. What you see is what you get with us. And we want to keep it that way. We are committed to our mission, the science behind it and the people working here. So, we will remove as many barriers as possible to help you excel. We’re in this to help patients and their families, so don’t mind us if we bulldoze through some obstacles for you.


We are INVESTED IN OUR PEOPLE. You’ll feel welcomed from day one. After all, we chose you for a reason. You’re super-skilled and we like you. That’s important. Therefore, we’ll give you the respect you deserve and invest in you to ensure you have the tools you need to succeed. You’ll feel confident in your role and add tremendous value all along the way.


Who says you can’t be PLAYFUL at work? We know what we’re doing is incredibly important and we strive to make a difference for those with high unmet medical needs. That said, we also like to bring out our competitive spirit in team Olympics, ping pong, potluck lunches and game night. We spend a great deal of time at work, so we want to make sure it’s energizing and enjoyable for all.


We launched Fulcrum Therapeutics with a BOLD SCIENTIFIC VISION: to change the course of genetically defined diseases by treating them at their root cause. Our patient-focused approach allows us to think creatively about the best way to modulate and balance gene expression and to deliver therapeutics to treat the known root cause of genetically defined diseases.

Join our team

We are committed to delivering new therapies to patients. We’re also dedicated to helping our employees grow professionally.

What should you expect at Fulcrum? Exciting science. Deep discussions. Supportive colleagues. Terrific benefits. Tremendous growth opportunities. A chance to engage and partner with the patient community. And of course, plenty of great food.

Explore our job openings:


Open positions

Don’t see the position you’re looking for? Please submit your CV to

Note to recruitment agencies: Please do not forward any agency resumes. Fulcrum Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Equal Opportunity Employer M/F/D/V

Fulcrum requires all employees to be fully vaccinated against COVID-19. This requirement is a condition of employment at Fulcrum, and it applies regardless of whether or not the position is located onsite at Fulcrum’s headquarters in Cambridge, MA. If you are unable to receive the vaccine due to a serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.