WE ARE RARE
Fulcrum is a great place to have a career. Why? Because we have the FULcrew! Our people make us great. At Fulcrum, you can count on finding coworkers who are passionate about their work. Our patient-centered, inclusive, and connected culture enables us to actively listen to the needs of the rare disease community as we lead our science. This makes us and our work rare!
Make your career a career with impact.
See our available roles below or connect with us at careers@fulcrumtx.com
Voices of Fulcrum
Meet the FULcrew and hear our stories.
Are you looking for consistency, commitment, and passion in your career? Join us.
There is always hope for change when people are committed to moving forward together every day, without exception. We call this steadfast commitment our "20 Mile March," inspired by Jim Collins' book Good to Great. At Fulcrum, we pledge to show up passionately every day, dedicated to our work and each other, no matter the challenges we face.
Explore our job openings:
Director, Patient Advocacy
Company Overview
Fulcrum Therapeutics, Inc. (“Fulcrum”) [NASDAQ: FULC] is a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum’s lead program in clinical development is pociredir, a small molecule designed to increase the expression of fetal hemoglobin for the treatment of sickle cell disease (SCD).
Description
Reporting to Head of Patient Advocacy, the Director of Patient Advocacy will oversee both the strategic and operational aspects of Fulcrum’s efforts to integrate the patient experience from discovery to commercialization. This position will vertically and horizontally integrate the patient experience into Fulcrum’s operating model to ensure the patient experience we deliver is best-in class. A focus on authenticity at every phase of the patient journey at Fulcrum will ensure all patients feel they are part of the Fulcrew while engaging with Fulcrum.
Responsibilities
Working cross-functionally with internal stakeholder including Government Affairs, Program Management, Program Leadership, Medical Affairs, and Clinical Operations
- In partnership with the Head of Patient Advocacy, build strategic roadmap of patient experience from discovery to commercialization that reflects insights and strategies that help elevate Fulcrum with the communities that it serves.
- Identify opportunities to generate insights and analytics related to patient and caregiver needs across the patient journey and spearheads the execution of these projects in conjunction with the patient services execution team.
- Supports both federal and state policy strategic planning activities to ensure that Fulcrum is positioned well to capital.
- Develop and maintain comprehensive, innovative, value-creating patient experience strategies, ensuring they maintain strategic prominence with key stakeholders!
- Identify industry best practices as well as innovative access services approaches that can improve the ability of Fulcrum to support patients.
- Monitor policy developments to ensure that Fulcrum is well informed and appropriately prepared for the evolving government oversight, regulatory environment, legal, and reputational landscape surrounding manufacturer-sponsored Access Services programs.
- Serve as a strategic planning resource to our internal teams in developing patient services resources across Fulcrum.
Qualifications
- Bachelor’s degree (Advanced degree preferred)
- Have worked in a pre-commercial or commercial rare disease company (preferred)
- 5+ years of a demonstrated track record of developing and implementing patient services programs and patient focused access solutions
- Recognized profile in the industry as a thought leader in patient support and documented ability to engage Senior Leadership on patient-focused support solutions
- Strong, demonstrated track record of connecting and combining ideas, designing pilots and metrics, and driving novel ideas to practical solutions across patient support teams
- Deep understanding of how to identify and address the emotional, physical, and financial barriers patients experience regarding obtaining their prescribed medications
- Understanding of the complex legal, regulatory, and compliance regulations and guidelines around access support program development and execution
Director/Senior Director, Head of Publications
About Fulcrum Therapeutics
Fulcrum Therapeutics, Inc. (“Fulcrum”) [NASDAQ: FULC] is a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum’s lead program in clinical development is pociredir, a small molecule designed to increase the expression of fetal hemoglobin for the treatment of sickle cell disease (SCD).
Position Summary
The Head of Publications will be responsible for leading the development and implementation of Fulcrum’s global publication strategy —including original scientific manuscripts, abstracts, and materials for scientific and patient advocacy audiences. This role will also oversee the timely and high-quality dissemination of clinical and health economics and outcomes research (HEOR) data, as well as the company’s representation across social media platforms.. Reporting to the Vice President, Clinical Development, this role will work cross-functionally with Clinical Development, Medical Affairs, and Regulatory teams to align publication activities with corporate and scientific communication objectives.
This is a hybrid role based in Cambridge, MA, requiring a minimum of 3 days on-site per week.
Key Responsibilities
- Develop and execute a comprehensive global publication strategy, ensuring alignment with Fulcrum’s scientific and medical objectives.
- Lead the planning, development, and dissemination of high-quality scientific publications, including manuscripts, abstracts, posters, and congress presentations.
- Collaborate cross-functionally with Clinical Development, Medical Affairs, and other key stakeholders to ensure a cohesive and strategic approach to data communication.
- Manage external agencies, writers, and vendors, ensuring publications adhere to timelines, budgets, and industry standards (ICMJE, GPP, etc.).
- Drive innovative approaches to scientific publications, including digital platforms and emerging communication channels.
- Ensure compliance with ethical, legal, and regulatory guidelines, including transparency and data-sharing requirements.
- Establish and oversee an efficient publication review process, maintaining scientific integrity, accuracy, and alignment with corporate messaging.
- Track and report key publication metrics to assess impact, optimize strategy, and drive continuous improvement.
- Provide leadership and mentorship to internal team members, fostering professional development and scientific excellence.
Qualifications
- Advanced degree (PhD, PharmD, MD, or equivalent) in a relevant scientific discipline.
- Minimum of 10 years of experience in medical publications within the biotech or pharmaceutical industry, ideally in rare diseases with focus on basic, translational and clinical research in benign and malignant hematology.
- Strong understanding of the publication process, industry guidelines, regulatory, scientific and GCP requirements.
- Track record of publications ideally related to basic, translational, and clinical research in benign and malignant hematology or rare genetically defined disease, featured in high-impact journals and presented at leading scientific meetings.Established network with leading KOLs and other key stakeholders relevant to the successful execution of a publication strategy.
- Experience and ability to plan and translate scientific literature into documents appropriate for non-scientific audiences, including patient advocacy groups, government affairs, and investors.
- Proven track record of developing and executing successful publication plans across multiple therapeutic areas.
- Experience working in a matrixed environment and leading cross-functional teams.
- Excellent communication and project management skills, with the ability to manage multiple priorities effectively.
- Experience with digital publication platforms and innovative publication strategies is a plus.
- Demonstrated ability to manage external vendors and publication budgets effectively.
Vice President, Head of Program Strategy
Location: Cambridge, MA (Hybrid)
About Fulcrum Therapeutics
Fulcrum Therapeutics, Inc. (“Fulcrum”) [NASDAQ: FULC] is a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need. Fulcrum’s lead program in clinical development is pociredir, a small molecule designed to increase the expression of fetal hemoglobin for the treatment of sickle cell disease (SCD).
Position Overview
We are seeking an experienced VP, Head of Program Strategy to lead and scale our program and project management efforts across the R&D pipeline. The ideal candidate will bring deep experience in biotech program leadership, with a strong track record of driving cross-functional teams to deliver on key milestones from discovery through development and commercialization. This individual will partner closely with R&D, Regulatory, and CMC teams to ensure efficient execution, resource alignment, and risk mitigation.
Given the high profile of this program, this leader will interact regularly with the Senior leaderships including the executive team and the board of directors, as well as with key external stakeholders including patient advocacy groups and thought leaders.
Responsibilities
- Lead program management for all development programs across preclinical, clinical, and commercial phases.
- Partner closely with cross-functional leaders (R&D, Clinical, Regulatory, CMC, Commercial, Finance) to drive strategic planning and execution.
- Develop and maintain integrated program plans including timelines, budgets, risk assessments, and resource needs.
- Lead regular team meetings, ensuring timely decision-making, issue resolution, and status reporting to executive leadership.
- Provide oversight and guidance to program managers; build and mentor a high-performing team.
- Serve as a key liaison between the program teams and executive leadership, enabling transparent and proactive communication.
- Drive implementation of tools, systems, and processes to scale and standardize program management practices.
- Contribute to corporate strategy, portfolio prioritization, and scenario planning.
Requirements:
- 10+ years of industry experience with 7+ years leading drug development programs
- Deep understanding of drug development, registration and pre-commercialization
- Track record as a strong collaborator who communicates in an open, direct, and timely manner
- Ability to adapt to changing conditions
- An authentic leader who builds and maintains strong relationships and trust, with exceptional ability to influence key stakeholders at all levels in a matrix environment
- Excel at communicating across all levels and functions – with ability to succinctly summarize complex issues and solutions to management
