WE ARE RARE
Fulcrum is a great place to have a career. Why? Because we have the FULcrew! Our people make us great. At Fulcrum, you can count on finding coworkers who are passionate about their work. Our patient-centered, inclusive, and connected culture enables us to actively listen to the needs of the rare disease community as we lead our science. This makes us and our work rare!
OUR VALUES:
Make your career a career with impact.
See our available roles below or connect with us at [email protected]










Voices of Fulcrum
Meet the FULcrew and hear our stories.
Are you looking for consistency, commitment, and passion in your career? Join us.
There is always hope for change when people are committed to moving forward together every day, without exception. We call this steadfast commitment our "20 Mile March," inspired by Jim Collins' book Good to Great. At Fulcrum, we pledge to show up passionately every day, dedicated to our work and each other, no matter the challenges we face.




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At Fulcrum, we celebrate the resilience and determination of people with Sickle Cell Disease during #BlackHistoryMonth and year round.

We hope everyone had a wonderful Super Bowl Sunday! 🏈 Last week, the FULcrew got into the spirit with a game-day party and some friendly competition. We played football squares at $5 each and donated 100% of the proceeds to the Massachusetts Sickle Cell Association—thank you to everyone who participated! And a big shoutout to Alyssa for winning our football trivia competition! 🏆
#GivingBack #SuperBowl

In the month leading up to #RareDiseaseDay, Fulcrum Therapeutics stands in solidarity with the rare disease community, including those affected by #SickleCellDisease. We are dedicated to developing innovative therapies that bring hope and improve the lives of those living with rare conditions.
#RareDiseaseAwareness #RareIsNotRare

What do dogs have to do with our work at Fulcrum? Hear from Genevieve as she reflects on an inspiring moment from a patient speaker that deeply resonated with her and fuels her passion for what we do.
#WeAreRare

Today, we honor the legacy of Dr. Martin Luther King Jr., whose unwavering commitment to justice and equality reminds us of the importance of fighting for those whose voices often go unheard.
In the rare disease community, this resonates deeply. We work every day to improve the lives of those with high unmet medical needs. Dr. King’s words inspire us to keep pushing forward: “The time is always right to do what is right.”
#RareDisease #MLK

Looking ahead to 2025, we’re reflecting on the incredible advocacy events we attended in 2024. Fulcrum was honored to join the Sickle Cell Community at over 20 events last year, and we’re excited to continue this important work in the year to come.
In 2025, we look forward to continuing to focus on improving the lives of patients with genetically defined diseases in areas of high unmet medical need.
#RareDisease #SCDAwareness

Kathleen`s patient-centered mindset shapes everything she does. Watch her video to discover how her approach makes a difference every day.

We had an incredible experience attending the 2024 Massachusetts Conference for Women! From inspiring keynote speakers to insightful breakout sessions, we embraced this year’s empowering theme, Power in Unity.
#ForgingForwardTogether

The FULcrew brought the holiday cheer to life with our annual cookie swap! 🍪✨
This year, we paired our sweet treats with a cozy hot chocolate bar. Cheers to a joyful holiday season and an incredible new year ahead!

At our last Fulcrum All Hands meeting of the year, we had the privilege of hosting a panel of experts from the patient, advocacy, and medical communities, who shared their insights on the future of Sickle Cell Disease and how the FULcrew can play a pivotal role in making a difference.
We asked each panelist what the SCD community hopes for…and what Fulcrum can do to help realize those hopes. Swipe through to see what they had to say.
In closing, our CEO, Alex Sapir, expressed his gratitude to the panelists: "I can’t thank you enough. Together, we’ll keep fighting the good fight, pushing forward, and marching ahead every day."
#SickleCellAwareness

Every November, our café transforms with the addition of our Gratitude Tree—a space where FULcrew members pause to reflect and share what they’re grateful for.
We’re incredibly thankful for our amazing FULcrew and the energy they bring every day. We hope everyone had a joyful and fulfilling Thanksgiving holiday!
#Gratitude #Thankful #FULcrew
