WE ARE RARE
Fulcrum is a great place to have a career. Why? Because we have the FULcrew! Our people make us great. At Fulcrum, you can count on finding coworkers who are passionate about their work. Our patient-centered, inclusive, and connected culture enables us to actively listen to the needs of the rare disease community as we lead our science. This makes us and our work rare!
OUR VALUES:
Make your career a career with impact.
See our available roles below or connect with us at [email protected]
Voices of Fulcrum
Meet the FULcrew and hear our stories.
Are you looking for consistency, commitment, and passion in your career? Join us.
There is always hope for change when people are committed to moving forward together every day, without exception. We call this steadfast commitment our "20 Mile March," inspired by Jim Collins' book Good to Great. At Fulcrum, we pledge to show up passionately every day, dedicated to our work and each other, no matter the challenges we face.
Explore our job openings:
Fulcrum Therapeutics was proud to attend the 2025 Foundation for Sickle Cell Disease Research (FSCDR) Conference in Ft. Lauderdale, Florida. This powerful gathering brought together research, advocacy, and lived experiences to drive progress toward a pain-free future.
From inspiring keynotes like Earvin "Magic" Johnson’s to meaningful conversations with clinicians, researchers, and community leaders, the event highlighted the importance of collaboration in improving outcomes for people living with sickle cell disease.
We’re honored to be part of the effort to reshape the future of SCD care.
#SickleCellAwareness #FSCDR2025
Our annual FULcrew Step Challenge was a massive success! The FULcrew stepped up (literally!) and moved together in support of wellness, connection, and a little friendly competition.
Congratulations to our top stepper, Brynne Yamamoto, and to team FULcrew Frenzy for leading the charge with over 2.2 million steps! 👏
Thank you to everyone who joined the challenge and helped us take steps toward better health together.
#FULcrew #StepChallenge
Today, on World Sickle Cell Day, we stand with the warriors, families, and advocates working tirelessly to raise awareness and push for progress. At Fulcrum, we`re committed to transforming the future of Sickle Cell Disease through research, science, and partnership.
#WorldSickleCellDay #SickleCellAwareness #RareDiseaseResearch
Today we honor Juneteenth.
At Fulcrum, we recognize the significance of this day and stand in solidarity with Black communities as we reflect on the past, honor progress, and renew our commitment to serving underserved communities through our mission.
#Juneteenth #DayOfFreedom
At the 5th Global Congress on Sickle Cell Disease in Abuja, Nigeria, Fulcrum Therapeutics proudly joined global leaders, clinicians, advocates, and researchers in the fight to advance care and research for people living with SCD.
From sharing updates on our clinical research to engaging in powerful conversations with patients and physicians, this experience reaffirmed our commitment to delivering meaningful change in communities that need it most.
Thank you to the Global Sickle Cell Disease Network, the Sickle Cell Support Society of Nigeria, and all the partners working to improve outcomes for people with SCD around the world.
Watch the highlights and hear from our CEO, Alex Sapir: https://www.youtube.com/watch?v=8S_4bGSHpUg
#SickleCellAwareness #GlobalSCDCongress
Men: your health matters. To your family, your team, and most of all, to you. Happy Father’s Day from all of us at Fulcrum!
#MensHealthMonth #FathersDay
The FULcrew just got bigger! Join us in welcoming 6 new team members. We’re so glad you’re here!
#WelcometotheFULcrew
The FULcrew hit it out of the park this week with an afternoon at Fenway just in time for a Red Sox walk-off win! ⚾ Nothing better than sunshine, team spirit, and a win to celebrate together.
#FULcrew #LifeAtFulcrum #BiotechCulture
Last week, we were proud to support The Just Society’s Day on Capitol Hill—amplifying the need for research, innovation, and better outcomes for patients with sickle cell disease.
The Just Society members engaged with 18 U.S. Representative and Senate offices to champion critical life sciences legislation. Special attention was paid to key legislation that looks to advance care for the sickle cell warrior community.
#SCDAwareness #RareDiseases #TJS #SCRED #SC101 #SCDAA #SC3 #SickleCellConsortium #SickCells #SCD #TheJustSociety
To celebrate #CulturalDiversityDay, we asked the FULcrew to bring in a dish that reflects their culture or background. It was a great way to share traditions, spark conversations, and enjoy food together!
#TeamCulture #FULcrew
Biotech is a journey of both triumphs and setbacks. Hear from the FULcrew on what keeps them driven through the ups and downs of this meaningful work.
#BiotechCareers #Resilience
This May, we celebrate…
🔬The women driving discovery
💪The mothers balancing science and caregiving
❤️The advocates and warriors fighting for better health outcomes
At Fulcrum, our mission is deeply personal. We honor the women behind every breakthrough—and the families counting on what comes next.
Happy Mother’s Day!
#MothersDay #WomensHealthMonth
