In a world of workforce changes, Fulcrum is a great place to have a career. Why? Because we have the FULcrew! Our people make us great. At Fulcrum, you can count on finding coworkers who are uniquely themselves, committed to patients, dedicated to the community, and intent on having fun.

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WE are the FULcrew and THIS is why we are here.

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We show up every day with commitment, purpose, and dedication to patients, the business, and each other.

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We create TRANSFORMATIVE therapies.

We are scientific leaders focused on creating therapies that transform the lives of patients and caregivers.

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We are unwavering in our COMMITMENT to DE&I.

We are committed to a diverse, welcoming, and unique culture that embraces and celebrates everyone. We strive to be as diverse as the community we serve.

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We are patient and community PARTNERS.

We actively listen to the needs of patients, caregivers, and our community as we lead our science. Patients and the advocacy community are the foundation of everything we do.

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We have a PEOPLE FOCUSED culture.

We invest in our people so we can learn, innovate, and grow together. Empowerment and camaraderie are pivotal to our progress.

Make your career a career with impact

See our available job roles below or connect with us at [email protected]

Voices of Fulcrum - Meet the FULcrew and hear our stories.

Bobby Riehle - VP, Corporate Strategy & PSL FSHD

In many industries and companies, it can be difficult to remember what the mission is. Here at Fulcrum, there's no doubt what our end goal is--it's to improve the lives of patients living with rare diseases.

Caroline - Principal Scientist

The whiteboard is a place where we spar some fun scientific debate. Like Caroline shares, we love having fun and challenging each other at Fulcrum.

Gabby L. - Senior Associate, People Experience

We are a purpose-driven company, and everyone knows it. We truly believe that we provide a place not just for an amazing career, but for a career with impact.

Join our team

We are committed to delivering new therapies to patients. We're also dedicated to helping our employees grow professionally.

What should you expect at Fulcrum? Exciting science. Deep discussions. Supportive colleagues. Terrific benefits. Tremendous growth opportunities. A chance to engage and partner with the patient community. And of course, plenty of great food.

Explore our job openings:

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Don't see the position you're looking for? Please submit your CV to [email protected]

Note to recruitment agencies:

Please do not forward any agency resumes. Fulcrum Therapeutics is not responsible for any fees related to resumes that are unsolicited.

Equal Opportunity Employer M/F/D/V

Fulcrum requires all employees to be fully vaccinated against COVID-19. This requirement is a condition of employment at Fulcrum, and it applies regardless of whether or not the position is located onsite at Fulcrum's headquarters in Cambridge, MA. If you are unable to receive the vaccine due to a serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.