All Fulcrum Publications

April 9, 2021

Discovery of Clinical Candidate FTX 6058: A Potent, Orally Bioavailable Upregulator of Fetal Hemoglobin for Treatment of Sickle Cell Disease

Ivan V. Efremov, Kingsley Kofi Appiah, Angela Cacace, Yanfei Dong, Shawn D. Johnstone, Steven Kazmirski, Qingyi Li, Christopher Moxham, Peter Rahl, Mark Roth, Billy Stuart, Lorin A. Thompson, III, Owen B. Wallace, Keqiang Xie, Feng Zhou

March 18, 2021

Quantitative Muscle Analysis in FSHD Using Whole Body MRI: Composite Muscle Measurements for Cross Sectional Analysis

Per Widholm, Markus Karlsson, André Ahlgren, Olof Dahlqvist Leinhard, Rabi Tawil, Kathryn Wagner, Jeffrey Statland, Leo Wang, Perry Shieh, Baziel Van Engelen, Diego Cadavid, Lucienne Ronco, Adefowope Odueyungbo, Jay Han, Maya Hatch, Michelle L. Mellion

March 18, 2021

In-Home Passive Measurements of Mobility and Sleep in FSHD Patients and their Relationship with Clinical Disease Severity Metrics

Rumen Hristov, Hariharan Rahul, Zachary Kabelac, Vicky Chan, Maya Hatch, Jay Han, Diego Cadavid, Michelle Mellion, Dina Katabi

March 18, 2021

An Optimized Timed Up and Go (TUG) for the Facioscapulohumeral Dystrophy (FSHD) Community

Vicky Chan, Maya Hatch, Michelle Mellion, Diego Cadavid, Jay Han

December 7, 2020

In vitro characterization of FTX-6058, a novel small molecule fetal hemoglobin inducer for sickle cell disease

Billy Stuart, Pete Rahl, Kingsley Appiah, Ivan Efremov, Lorin A Thompson, Owen Wallace, Christopher Moxham

December 7, 2020

FTX-6058, a novel HbF-inducing agent for the treatment of Sickle Cell Disease and b-Thalassemia

Billy Stuart, Keqiang Xie, Mark Roth, Steven Kazmirski, Kinglsey Appiah, Richard Barnes, Qingyi Li, David Peters, Lucienne Ronco, Kim Stickland, Paul Bruno, Diego Cadavid, Lorin Thompson, Owen Wallace, Ivan Efremov, and Peter Rahl

December 7, 2020

In vivo characterization of FTX-6058, a novel small molecule fetal hemoglobin inducer for sickle cell disease

Keqiang Xie, Mark Roth, Ivan Efremov, Serena Silver, Lucienne Ronco, Lorin A Thompson, Kim Stickland, Christopher Moxham and Owen Wallace

October 1, 2020

Development and Evaluation of a Whole-body MRI Protocol and Analysis Algorithms to Measure Changes in Skeletal Muscle in FSHD

Diego Cadavid, Michelle Mellion, Shane Raines, Per Widholm, and Olof Dahlqvist Leinhard

October 1, 2020

A Biomarker of Aberrant DUX4 Activity to Evaluate Losmapimod Treatment Effect in FSHD Phase 2 Trials

Lucienne Ronco, Kathryn Wagner, Diego Cadavid, Jayashree Chadchankar, Aaron Chang, Michelle Mellion, Adefowope Odueyungbo, Shane Raines, Anugraha Raman, Alan Robertson, Alejandro Rojas, Ning Shen, Perry Shieh, Jeffrey Statland, Rabi Tawil, Stephen Tapscott, Baziel van Engelen, Leo Wang, Nick Johnson, Owen Wallace

October 1, 2020

Open-Label Pilot Study of Losmapimod in FSHD1 (NCT04004000)

Joost Kools, Nicol Voermans, Karlien Mul, Lucienne Ronco, Adefowope Odueyungbo, Venkateswarlu Kondragunta, Kelly Marshall, Mary Bylo, Michelle Mellion, Baziel van Engelen, Diego Cadavid